Vivitrol is a proven medication used to treat alcohol and opioid addiction by blocking cravings and preventing relapse. While it’s an effective tool for recovery, understanding its potential long-term side effects is crucial for making informed decisions about your treatment.
This comprehensive guide explores the risks, safety considerations, and how CMAR in Denver can help you navigate your recovery journey with confidence.
Potential Long-Term Side Effects of Vivitrol
While Vivitrol is generally safe for long-term use, some individuals may experience more serious side effects over time.
Here’s a detailed look at the potential long-term side effects of Vivitrol:
1. Liver Health
- Risk: Long-term use of Vivitrol may affect liver function, though this is rare. Naltrexone is metabolized in the liver, and high doses over time could potentially lead to liver damage.
- Prevention: Regular liver function tests are recommended to monitor for any issues. If you have a history of liver disease, discuss this with your healthcare provider before starting Vivitrol.
2. Depression and Mood Changes
- Risk: Some individuals report mood changes, including depression, anxiety, or irritability, while on Vivitrol. This is more common in those with a history of mental health conditions.
- Prevention: If you experience mood changes, inform your healthcare provider immediately. They may adjust your treatment plan or recommend additional support, such as therapy or counseling.
3. Injection Site Reactions
- Risk: Repeated injections can sometimes cause tissue damage, scarring, or infections at the injection site.
- Prevention: Rotating injection sites and ensuring proper administration techniques can help minimize this risk. Always have Vivitrol injections administered by a qualified healthcare professional.
4. Hormonal Changes
- Risk: In rare cases, Vivitrol may impact hormone levels, leading to changes in menstrual cycles, libido, or energy levels.
- Prevention: If you notice unusual hormonal changes, discuss them with your healthcare provider. They may recommend further testing or adjustments to your treatment plan.
5. Allergic Reactions
- Risk: Although uncommon, severe allergic reactions to Vivitrol can occur. Symptoms may include rash, swelling, difficulty breathing, or anaphylaxis.
- Prevention: If you have a history of allergies, inform your healthcare provider before starting Vivitrol. Seek immediate medical attention if you experience signs of an allergic reaction.

Who is at Risk for Long-Term Side Effects?
Certain factors may increase the risk of experiencing long-term side effects of Vivitrol, including:
- Pre-existing liver conditions: Individuals with liver disease or impaired liver function may be at higher risk for liver-related side effects.
- Mental health history: Those with a history of depression, anxiety, or other mental health conditions may be more susceptible to mood changes.
- Allergies: Individuals with allergies to naltrexone or other medications should use Vivitrol with caution.
- Poor adherence to monitoring: Skipping regular check-ups or liver function tests can increase the risk of undetected side effects.
If you have any of these risk factors, discuss them with your healthcare provider before starting Vivitrol.
What is Vivitrol?
Vivitrol is an injectable form of naltrexone, a medication approved by the FDA to treat alcohol and opioid dependence. It works by blocking opioid receptors in the brain, reducing cravings, and preventing the euphoric effects of opioids and alcohol.
Administered as a monthly injection, Vivitrol is often used as part of a medication-assisted treatment (MAT) program. Unlike some other MAT medications, Vivitrol is non-addictive and does not require daily dosing, making it a convenient option for many individuals.
Common Side Effects of Vivitrol
Like any medication, Vivitrol can cause side effects. Most are mild and temporary, including:
- Nausea
- Headache
- Fatigue
- Dizziness
- Injection site reactions (e.g., pain, swelling, or redness)
These side effects typically subside as your body adjusts to the medication. However, it’s important to discuss any persistent or severe symptoms with your healthcare provider.

How to Minimize Risks While Using Vivitrol
To ensure safe and effective treatment, follow these guidelines:
- Regular Monitoring:
- Schedule routine liver function tests and medical check-ups to catch any potential issues early.
- Open Communication:
- Report any side effects to your healthcare provider immediately. They can adjust your treatment plan if needed.
- Healthy Lifestyle:
- Maintain a balanced diet, exercise regularly, and avoid alcohol or opioids to support your overall health.
- Follow Dosage Guidelines:
- Adhere to your prescribed treatment plan and attend all scheduled injections.
- Work with a Trusted Provider:
- Choose a reputable treatment center like CMAR in Denver, Colorado, to ensure you receive high-quality care and monitoring.
Why Choose CMAR for Vivitrol Treatment in Denver, Colorado?
At CMAR (Colorado Medication Assisted Recovery), we prioritize your safety and well-being.
Our team specializes in medication-assisted treatment, including Vivitrol, and provides personalized care to help you achieve lasting recovery. Here’s why we stand out:
- Expertise: We have extensive experience in MAT and are committed to using evidence-based practices.
- Compassionate Care: We take a personalized approach to treatment, ensuring you receive the support you need.
- Safety First: We monitor for side effects and provide regular check-ups to ensure your treatment is safe and effective.
- Local Focus: As a Denver-based provider, we’re dedicated to serving our community with high-quality, affordable care.
FAQs About Vivitrol Long-Term Side Effects
Yes, Vivitrol is generally safe for long-term use when monitored by a healthcare provider.
While rare, long-term use of Vivitrol may affect liver function. Regular monitoring is recommended.
Contact your healthcare provider immediately to discuss your symptoms and adjust your treatment plan if necessary.
Regular check-ups, including liver function tests, are typically recommended every few months.
Yes, other MAT options include Suboxone and methadone. Your healthcare provider can help you choose the best treatment for your needs.
Make an Informed Decision About Vivitrol
Understanding the potential long-term side effects of Vivitrol is an important part of your recovery journey. While Vivitrol is a safe and effective treatment for many, it’s essential to work with a trusted healthcare provider to monitor for any risks.
At CMAR in Denver, Colorado, we’re here to support you every step of the way.